Article
Simultaneous Genotyping of α-Thalassemia Deletional and Nondeletional Mutations by Real-Time PCR-Based Multicolor Melting Curve Analysis.
The Journal of molecular diagnostics : JMD - 1 Jul 2017
Huang Qiuying, Wang Xudong, Tang Ning, Yan Tizhen, Chen Ping, Li Qingge
Abstract excerpt
α-Thalassemia, which is caused by defective synthesis of the hemoglobin α-globin chains, is the most commonly inherited recessive hemoglobin abnormality. Genetic detection of a defective α-globin gene is challenging because of a variety of large deletions of the α-globin gene cluster and nondeletional mutations. Separate detections of them are often required using complex and error-prone open-tube methods. We...
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