Article
Mutations in CHD2 cause defective association with active chromatin in chronic lymphocytic leukemia.
Blood - 9 Jul 2015
Rodríguez David, Bretones Gabriel, Quesada Víctor, Villamor Neus, Arango Javier R, López-Guillermo Armando, Ramsay Andrew J, Baumann Tycho, Quirós Pedro M, Navarro Alba, Royo Cristina, Martín-Subero José I, Campo Elías, López-Otín Carlos
Abstract excerpt
Great progress has recently been achieved in the understanding of the genomic alterations driving chronic lymphocytic leukemia (CLL). Nevertheless, the specific molecular mechanisms governing chromatin remodeling in CLL are unknown. Here we report the genetic and functional characterization of somatic mutations affecting the chromatin remodeler CHD2, one of the most frequently mutated genes in CLL (5.3%) and in...
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