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Article

Construction of a population-specific HLA imputation reference panel and its application to Graves' disease risk in Japanese.

Nature genetics - 1 Jul 2015

Okada Yukinori, Momozawa Yukihide, Ashikawa Kyota, Kanai Masahiro, Matsuda Koichi, Kamatani Yoichiro, Takahashi Atsushi, Kubo Michiaki

Abstract excerpt

To fine map association signals of human leukocyte antigen (HLA) variants in the major histocompatibility complex (MHC) region, we constructed a Japanese population-specific reference panel (n = 908). We conducted trans-ancestry comparisons of linkage disequilibrium (LD) and haplotype structure for HLA variants using an entropy-based LD measurement, ɛ, and a visualization tool to capture high-dimensional...

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Identifiers

PMID: 26029868
DOI: 10.1038/ng.3310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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