Article
A high-resolution haplotype-resolved Reference panel constructed from the China Kadoorie Biobank Study.
Nucleic acids research - 27 Nov 2023
Yu Canqing, Lan Xianmei, Tao Ye, Guo Yu, Sun Dianjianyi, Qian Puyi, Zhou Yuwen, Walters Robin G, Li Linxuan, Zhu Yunqing, Zeng Jingyu, Millwood Iona Y, Guo Ruidong, Pei Pei, Yang Tao, Du Huaidong, Yang Fan, Yang Ling, Ren Fangyi, Chen Yiping, Chen Fengzhen, Jiang Xiaosen, Ye Zhiqiang, Dai Lanlan, Wei Xiaofeng, Xu Xun, Yang Huanming, Wang Jian, Chen Zhengming, Zhu Huanhuan, Lv Jun, Jin Xin, Li Liming
Abstract excerpt
Precision medicine depends on high-accuracy individual-level genotype data. However, the whole-genome sequencing (WGS) is still not suitable for gigantic studies due to budget constraints. It is particularly important to construct highly accurate haplotype reference panel for genotype imputation. In this study, we used 10 000 samples with medium-depth WGS to construct a reference panel that we named the CKB...
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