Article
Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia.
Stem cell reports - 12 Aug 2014
Spencer C Ian, Baba Shiro, Nakamura Kenta, Hua Ethan A, Sears Marie A F, Fu Chi-cheng, Zhang Jianhua, Balijepalli Sadguna, Tomoda Kiichiro, Hayashi Yohei, Lizarraga Paweena, Wojciak Julianne, Scheinman Melvin M, Aalto-Setälä Katriina, Makielski Jonathan C, January Craig T, Healy Kevin E, Kamp Timothy J, Yamanaka Shinya, Conklin Bruce R
Abstract excerpt
Long-QT syndrome mutations can cause syncope and sudden death by prolonging the cardiac action potential (AP). Ion channels affected by mutations are various, and the influences of cellular calcium cycling on LQTS cardiac events are unknown. To better understand LQTS arrhythmias, we performed current-clamp and intracellular calcium ([Ca(2+)]i) measurements on cardiomyocytes differentiated from patient-derived...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.