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Article

Diabetic silkworms for evaluation of therapeutically effective drugs against type II diabetes.

Scientific reports - 29 May 2015

Matsumoto Yasuhiko, Ishii Masaki, Hayashi Yohei, Miyazaki Shinya, Sugita Takuya, Sumiya Eriko, Sekimizu Kazuhisa

Abstract excerpt

We previously reported that sugar levels in the silkworm hemolymph, i.e., blood, increase immediately (within 1 h) after intake of a high-glucose diet, and that the administration of human insulin decreases elevated hemolymph sugar levels in silkworms. In this hyperglycemic silkworm model, however, administration of pioglitazone or metformin, drugs used clinically for the treatment of type II diabetes, have no...

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Identifiers

PMID: 26024298
DOI: 10.1038/srep10722
PMCID: PMC4448660

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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