Article
In vivo high-resolution magic angle spinning proton NMR spectroscopy of Drosophila melanogaster flies as a model system to investigate mitochondrial dysfunction in Drosophila GST2 mutants.
International journal of molecular medicine - 1 Jul 2014
Righi Valeria, Apidianakis Yiorgos, Psychogios Nikolaos, Rahme Laurence G, Tompkins Ronald G, Tzika A Aria
Abstract excerpt
In vivo nuclear magnetic resonance spectroscopy (NMR), a non-destructive biochemical tool used for investigating live organisms, has recently been performed in studies of the fruit fly Drosophila melanogaster, a useful model organism for investigating genetics and physiology. We used a novel high-resolution magic angle-spinning (HRMAS) NMR method to investigate live Drosophila GST2 mutants using a conventional...
Topics
- Animals
- Apoptosis
- Drosophila Proteins
- Drosophila melanogaster
- Glutathione Transferase
- Insulin
- Insulin Resistance
- Lipids
- Magnetic Resonance Spectroscopy
- Male
- Metabolome
- Mitochondria
- Muscle, Skeletal