Article
EIF4G1 mutations do not cause Parkinson's disease.
Neurobiology of aging - 1 Aug 2015
Nichols Noah, Bras Jose M, Hernandez Dena G, Jansen Iris E, Lesage Suzanne, Lubbe Steven, Singleton Andrew B
Abstract excerpt
EIF4G1 mutations were previously reported as a cause of Parkinson's disease (PD). As a result of this finding, considerable work has been performed to test this idea and to examine the functional role of eukaryotic translation initiation factor 4-gamma in the pathogenic process underlying PD. Here, we show that the originally described mutation is likely a rare benign variant. We tested this variant in a very...
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