Article
Variants in eukaryotic translation initiation factor 4G1 in sporadic Parkinson's disease.
Neurogenetics - 1 Aug 2012
Schulte Eva C, Mollenhauer Brit, Zimprich Alexander, Bereznai Benjamin, Lichtner Peter, Haubenberger Dietrich, Pirker Walter, Brücke Thomas, Molnar Maria J, Peters Annette, Gieger Christian, Trenkwalder Claudia, Winkelmann Juliane
Abstract excerpt
Recently, mutations in eukaryotic translation initiation factor 4G1 (EIF4G1) were reported as a rare cause of familial Parkinson's disease (PD). We screened the 33 exons of EIF4G1 by high-resolution melting curve analysis for variants in our Central European cohort of 376 PD cases. Variant frequency was assessed in a total of 975 PD cases and 1,014 general population controls. Eight novel nonsynonymous and four...
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