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Article

Solitary fibrous tumors: loss of chimeric protein expression and genomic instability mark dedifferentiation.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Aug 2015

Dagrada Gian P, Spagnuolo Rosalin D, Mauro Valentina, Tamborini Elena, Cesana Luca, Gronchi Alessandro, Stacchiotti Silvia, Pierotti Marco A, Negri Tiziana, Pilotti Silvana

Abstract excerpt

Solitary fibrous tumors, which are characterized by their broad morphological spectrum and unpredictable behavior, are rare mesenchymal neoplasias that are currently divided into three main variants that have the NAB2-STAT6 gene fusion as their unifying molecular lesion: usual, malignant and dedifferentiated solitary fibrous tumors. The aims of this study were to validate molecular and...

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Source

Identifiers

PMID: 26022454
DOI: 10.1038/modpathol.2015.70

Genes

STAT6
NAB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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