Article
Deep Sequencing of HIV-1 in Cerebrospinal Fluid.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Sept 2015
Tong Cheuk Yan William, Costelloe Sinead, Hubb Jonathan, Mullen Jane, O'Shea Siobhan, Marta Monica, Kulasegaram Ranjababu, Rackstraw Simon
Abstract excerpt
Using deep sequencing, human immunodeficiency virus (HIV) resistance-associated mutations were detected as minority species in the cerebrospinal fluid (CSF) of 4 patients with higher HIV type 1 RNA load in CSF than in plasma, but not in 2 patients with higher plasma viral load. Deep sequencing could help our understanding of viral escape in the central nervous system.
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