Article
High Viral Diversity and Mixed Infections in Cerebral Spinal Fluid From Cases of Varicella Zoster Virus Encephalitis.
The Journal of infectious diseases - 5 Oct 2018
Depledge Daniel P, Cudini Juliana, Kundu Samit, Atkinson Claire, Brown Julianne R, Haque Tanzina, Houldcroft Charlotte J, Koay Evelyn S, McGill Fiona, Milne Richard, Whitfield Tom, Tang Julian W, Underhill Gillian, Bergstrom Tomas, Norberg Peter, Goldstein Richard, Solomon Tom, Breuer Judith
Abstract excerpt
Background: Varicella zoster virus (VZV) may cause encephalitis, both with and without rash. Here we investigate whether viruses recovered from the central nervous system (CNS; encephalitis or meningitis) differ genetically from those recovered from non-CNS samples. Methods: Enrichment-based deep sequencing of 45 VZV genomes from cerebral spinal fluid (CSF), plasma, bronchoalveolar lavage (BAL), and vesicles was...
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