Ninety-day survival rate of patients with sepsis relates to programmed cell death 1 genetic polymorphism rs11568821.

doi:10.2310/JIM.0000000000000059

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Article

Ninety-day survival rate of patients with sepsis relates to programmed cell death 1 genetic polymorphism rs11568821.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research - 1 Mar 2014

Mansur Ashham, Hinz José, Hillebrecht Bronja, Bergmann Ingo, Popov Aron Frederik, Ghadimi Michael, Bauer Martin, Beissbarth Tim, Mihm Sabine

Abstract excerpt

BACKGROUND: Sepsis is a life-threatening condition. Programmed cell death 1 protein (PD-1), a negative costimulatory molecule, is suggested to be involved in pathogenesis as mortality is associated with high expression and as neutralizing antibodies improve survival in a mouse model. The PD-1 gene harbors an intronic single-nucleotide polymorphism, rs11568821, which is located in a transcription factor-binding...

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PMID: 24463978
DOI: 10.2310/JIM.0000000000000059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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