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Blocking tumor growth by targeting autophagy and SQSTM1 in vivo

4 May 2015

Abstract excerpt

Autophagy is a highly conserved cellular process for degradation of bulk cytoplasmic materials in response to starvation and maintenance of cellular homeostasis. Dysfunction of autophagy is implicated in a variety of diseases including cancer. In a recent study, we devised a system for inducible deletion of an essential autophagy gene Rb1cc1/Fip200 in established tumor cells in vivo and showed that Rb1cc1 is...

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PMID: 26020424
DOI: 10.1080/15548627.2015.1048173

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