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Article

The role of mitochondrial DNA mutation on neurodegenerative diseases.

Experimental & molecular medicine - 13 Mar 2015

Cha Moon-Yong, Kim Dong Kyu, Mook-Jung Inhee

Abstract excerpt

Many researchers have reported that oxidative damage to mitochondrial DNA (mtDNA) is increased in several age-related disorders. Damage to mitochondrial constituents and mtDNA can generate additional mitochondrial dysfunction that may result in greater reactive oxygen species production, triggering a circular chain of events. However, the mechanisms underlying this vicious cycle have yet to be fully investigated....

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Identifiers

PMID: 25766619
DOI: 10.1038/emm.2014.122
PMCID: PMC4351410

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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