Article
Listeriolysin O mediates cytotoxicity against human brain microvascular endothelial cells.
FEMS microbiology letters - 1 Jun 2015
Zhang Ting, Bae Dongryeoul, Wang Chinling
Abstract excerpt
Penetration of the brain microvascular endothelial layer is one of the routes Listeria monocytogenes use to breach the blood-brain barrier. Because host factors in the blood severely limit direct invasion of human brain microvascular endothelial cells (HBMECs) by L. monocytogenes, alternative mechanisms might be used by this bacterium to penetrate the endothelial cell layer. In this study, we evaluated the...
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