Article
Genetic epidemiology and nonsyndromic structural birth defects: from candidate genes to epigenetics.
JAMA pediatrics - 1 Apr 2014
Hobbs Charlotte A, Chowdhury Shimul, Cleves Mario A, Erickson Stephen, MacLeod Stewart L, Shaw Gary M, Shete Sanjay, Witte John S, Tycko Benjamin
Abstract excerpt
Birth defects are a leading cause of infant morbidity and mortality worldwide. The vast majority of birth defects are nonsyndromic, and although their etiologies remain mostly unknown, evidence supports the hypothesis that they result from the complex interaction of genetic, epigenetic, environmental, and lifestyle factors. Since our last review published in 2002 describing the basic tools of genetic epidemiology...
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