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Article

Identification and modulation of the key amino acid residue responsible for the pH sensitivity of neoculin, a taste-modifying protein.

PloS one - 29 Apr 2011

Nakajima Ken-ichiro, Yokoyama Kanako, Koizumi Taichi, Koizumi Ayako, Asakura Tomiko, Terada Tohru, Masuda Katsuyoshi, Ito Keisuke, Shimizu-Ibuka Akiko, Misaka Takumi, Abe Keiko

Abstract excerpt

Neoculin occurring in the tropical fruit of Curculigo latifolia is currently the only protein that possesses both a sweet taste and a taste-modifying activity of converting sourness into sweetness. Structurally, this protein is a heterodimer consisting of a neoculin acidic subunit (NAS) and a neoculin basic subunit (NBS). Recently, we found that a neoculin variant in which all five histidine residues are replaced...

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PMID: 21559382
DOI: 10.1371/journal.pone.0019448
PMCID: PMC3084864

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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