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Article

Organometallic compounds with biological activity: a very selective and highly potent cellular inhibitor for glycogen synthase kinase 3.

Chembiochem : a European journal of chemical biology - 1 Sept 2006

Atilla-Gokcumen G Ekin, Williams Douglas S, Bregman Howard, Pagano Nicholas, Meggers Eric

Abstract excerpt

A chiral second-generation organoruthenium half-sandwich compound is disclosed that shows a remarkable selectivity and cellular potency for the inhibition of glycogen synthase kinase 3 (GSK-3). The selectivity was evaluated against a panel of 57 protein kinases, in which no other kinase was inhibited to the same extent, with a selectivity window of at least tenfold to more than 1000-fold at 100 microM ATP....

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Identifiers

PMID: 16858717
DOI: 10.1002/cbic.200600117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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