Effect of TP53 16-bp and β-TrCP 9-bp INS/DEL polymorphisms in relation to risk of breast cancer.

doi:10.1016/j.gene.2015.05.048

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Article

Effect of TP53 16-bp and β-TrCP 9-bp INS/DEL polymorphisms in relation to risk of breast cancer.

Gene - 1 Sept 2015

Eskandari-Nasab Ebrahim, Hashemi Mohammad, Amininia Shadi, Ebrahimi Mahboubeh, Rezaei Maryam, Hashemi Seyed Mehdi

Abstract excerpt

P53 as a tumor suppressor and an apoptosis modulator, is the regulator of the cell cycle and apoptosis, and contributes to mammary gland development and breast cancer (BC) progression. BTRC gene (Homo sapiens beta-transducing repeat containing E3 ubiquitin protein ligase) encoded protein, β-TrCP, is a novel regulator of p53. The current study aimed to assess the possible effects of TP53 IVS3 16 bp (rs17878362)...

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PMID: 26003292
DOI: 10.1016/j.gene.2015.05.048

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