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Article

Polymorphisms in VEGFA gene affect the antihypertensive responses to enalapril.

European journal of clinical pharmacology - 1 Aug 2015

Oliveira-Paula G H, Lacchini R, Fontana V, Silva P S, Biagi C, Tanus-Santos Jose E

Abstract excerpt

PURPOSE: Vascular endothelial growth factor (VEGF) is a potent angiogenic factor that affects blood pressure by promoting vasodilation mediated by nitric oxide. Angiotensin-converting enzyme inhibitors (ACEi) up-regulate the VEGF expression; thus, genetic polymorphisms in the VEGFA gene could affect the antihypertensive responses to these drugs. METHODS: Hypertensive patients (n = 102) were prospectively treated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26002049
DOI: 10.1007/s00228-015-1872-5

Genes

VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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