Article
CD229 is expressed on the surface of plasma cells carrying an aberrant phenotype and chemotherapy-resistant precursor cells in multiple myeloma.
Human vaccines & immunotherapeutics - 1 Jan 2015
Yousef Sara, Kovacsovics-Bankowski Magdalena, Salama Mohamed E, Bhardwaj Neelam, Steinbach Mary, Langemo Amanda, Kovacsovics Tibor, Marvin James, Binder Mascha, Panse Jens, Kröger Nicolaus, Luetkens Tim, Atanackovic Djordje
Abstract excerpt
Multiple Myeloma (MM) is a plasma cell (PC) malignancy, which despite significant therapeutic advances, is still considered incurable. This is due to the persistence of chemotherapy-resistant minimal residual disease in the patients' bone marrow (BM) after an effective induction therapy. Immunotherapies targeting surface molecules expressed on the bulk of tumor cells and the chemotherapy-resistant,...
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