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Article

Immunosurveillance and therapy of multiple myeloma are CD226 dependent.

The Journal of clinical investigation - 1 May 2015

Guillerey Camille, Ferrari de Andrade Lucas, Vuckovic Slavica, Miles Kim, Ngiow Shin Foong, Yong Michelle C R, Teng Michele W L, Colonna Marco, Ritchie David S, Chesi Marta, Chesi Martha, Bergsagel P Leif, Hill Geoffrey R, Smyth Mark J, Martinet Ludovic

Abstract excerpt

Multiple myeloma (MM) is an age-dependent hematological malignancy. Evaluation of immune interactions that drive MM relies on in vitro experiments that do not reflect the complex cellular stroma involved in MM pathogenesis. Here we used Vk*MYC transgenic mice, which spontaneously develop MM, and demonstrated that the immune system plays a critical role in the control of MM progression and the response to...

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Source

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Identifiers

PMID: 25893601
DOI: 10.1172/JCI77181
PMCID: PMC4463191

Genes

CD226
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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