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Article

Pyruvate kinase isoform M2 (PKM2) participates in multiple myeloma cell proliferation, adhesion and chemoresistance.

Leukemia research - 1 Dec 2015

He Yunhua, Wang Yuchan, Liu Hong, Xu Xiaohong, He Song, Tang Jie, Huang Yuejiao, Miao Xiaobing, Wu Yaxun, Wang Qiru, Cheng Chun

Abstract excerpt

Cell adhesion mediated drug resistance (CAM-DR) remains the major barrier in human multiple myeloma (MM) therapy. In the present study, we aimed at investigating the role of pyruvate kinase isoform M2 (PKM2) in MM CAM-DR. We determined that PKM2 expression was positively correlated with cell proliferation and knockdown of PKM2 contributed to the increased cell adhesion rate in MM. The enhancement in the adhesion...

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PMID: 26453405
DOI: 10.1016/j.leukres.2015.09.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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