Article
Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model.
PLoS genetics - 1 May 2015
Rahman Shamim H, Kuehle Johannes, Reimann Christian, Mlambo Tafadzwa, Alzubi Jamal, Maeder Morgan L, Riedel Heimo, Fisch Paul, Cantz Tobias, Rudolph Cornelia, Mussolino Claudio, Joung J Keith, Schambach Axel, Cathomen Toni
Abstract excerpt
In vitro disease modeling based on induced pluripotent stem cells (iPSCs) provides a powerful system to study cellular pathophysiology, especially in combination with targeted genome editing and protocols to differentiate iPSCs into affected cell types. In this study, we established zinc-finger nuclease-mediated genome editing in primary fibroblasts and iPSCs generated from a mouse model for radiosensitive severe...
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