Article
RPPA-based protein profiling reveals eIF4G overexpression and 4E-BP1 serine 65 phosphorylation as molecular events that correspond with a pro-survival phenotype in chronic lymphocytic leukemia.
Oncotarget - 10 Jun 2015
Shull Austin Y, Noonepalle Satish K, Awan Farrukh T, Liu Jimei, Pei Lirong, Bollag Roni J, Salman Huda, Ding Zhiyong, Shi Huidong
Abstract excerpt
Chronic lymphocytic leukemia (CLL), the most common adult leukemia, remains incurable despite advancements in treatment regimens over the past decade. Several expression profile studies have been pursued to better understand CLL pathogenesis. However, these large-scale studies only provide information at the transcriptional level. To better comprehend the differential protein changes that take place in CLL, we...
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