Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hepatitis C Virus Core Mutations Associated with False-Negative Serological Results for Genotype 3a Core Antigen.

Journal of clinical microbiology - 1 Aug 2015

Nguyen Linh Thuy, Dunford Linda, Freitas Ines, Holder Paul, Nguyen Lan Anh, O'Gorman Joanne, Connell Jeff, Carr Michael, Hall William, De Gascun Cillian

Abstract excerpt

Genetic characterization of the genotype 3a (GT3a) hepatitis C virus (HCV) core region from HCV core antigen (HCVcAg)-negative/RNA-positive cases and HCVcAg-positive/RNA-positive controls identified significant associations between the substitutions A48T and T49A/P and failure to detect HCVcAg (P < 0.05). Polymorphisms at residues 48 and 49 in the core protein are present across all major epidemic and endemic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Viral
Share to False Negative Reactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepacivirus

Share to Hepatitis C

Share to Mutant Proteins

Share to Mutation, Missense

Share to Serologic Tests

Share to Viral Core Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 25994168
DOI: 10.1128/JCM.01062-15
PMCID: PMC4508445

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Hepatitis C Virus Core Mutations Associated with False-Negative Serological Results for Genotype 3a Core Antigen.PMID 25994168Read ↗

Real-world utility of HCV core antigen as an alternative to HCV RNA testing: Implications for viral load and genotype.Semantic proximity Read ↗

Hepatitis C virus genotypes in clinical specimens tested at a national reference testing laboratory in the United States.Semantic proximity Read ↗

Hepatitis C virus core mutations reduce the sensitivity of a fluorescence enzyme immunoassay.Semantic proximity Read ↗

Identification of hepatitis C virus genotype 3 by a commercial assay challenged by natural polymorphisms detected in Spain from patients with diverse origins.Semantic proximity Read ↗

Detection of the NS3 Q80K polymorphism by Sanger and deep sequencing in hepatitis C virus genotype 1a strains in the UK.Semantic proximity Read ↗

The pan-genotype specificity of the hepatitis C virus anti-core monoclonal antibody C7-50 is contingent on the quasispecies profile of a population.Semantic proximity Read ↗

Evaluation of hepatitis C virus core antigen assays in detecting recombinant viral antigens of various genotypes.Semantic proximity Read ↗

Impact of HCV core gene quasispecies on hepatocellular carcinoma risk among HALT-C trial patients.Semantic proximity Read ↗

Relevance of RIBA-3 supplementary test to HCV PCR positivity and genotypes for HCV confirmation of blood donors.Semantic proximity Read ↗

The analytic sensitivity and mutant detection capability of six hepatitis B surface antigen assays.Semantic proximity Read ↗

Amino Acid Substitutions in Genotype 3a Hepatitis C Virus Polymerase Protein Affect Responses to SofosbuvirSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.