Article
Hepatitis C virus core mutations reduce the sensitivity of a fluorescence enzyme immunoassay.
Journal of clinical microbiology - 1 Sept 2000
Tokita H, Kaufmann G R, Matsubayashi M, Okuda I, Tanaka T, Harada H, Mukaide M, Suzuki K, Cooper D A
Abstract excerpt
Four of 107 samples obtained from hepatitis C virus (HCV) carriers showed lower HCV core antigen levels in a fluorescence enzyme immunoassay (FEIA) than expected from corresponding HCV RNA levels. Nucleotide sequencing revealed a mutation in the HCV core region (Thr49Pro) that appears to have reduced the FEIA sensitivity.
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