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Article

A candidate gene study reveals association between a variant of the Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) gene and systemic sclerosis.

Arthritis research & therapy - 19 May 2015

Marangoni Roberta Goncalves, Korman Benjamin D, Allanore Yannick, Dieude Philippe, Armstrong Loren L, Rzhetskaya Margarita, Hinchcliff Monique, Carns Mary, Podlusky Sofia, Shah Sanjiv J, Ruiz Barbara, Hachulla Eric, Tiev Kiet, Cracowski Jean-Luc, Varga John, Hayes M Geoffrey

Abstract excerpt

INTRODUCTION: The multifunctional nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ) has potent anti-fibrotic effects, and its expression and activity are impaired in patients with systemic sclerosis (SSc). We investigated PPAR-γ gene (PPARG) single nucleotide polymorphism...

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Identifiers

PMID: 25986483
DOI: 10.1186/s13075-015-0641-2
PMCID: PMC4437446

Genes

PPARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25986483-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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