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Article

Extracellular vesicles of Clonorchis sinensis promote the malignant phenotypes of cholangiocarcinoma via NF-κB/EMT axis.

PLoS neglected tropical diseases - 1 Oct 2024

Pan Xiaowen, He Qing, Yin Yingxuan, Xu Anyuan, Wu Aoxun, Yi Xueqing, Zhong Zifeng, Wu Yinjuan, Li Xuerong

Abstract excerpt

Clonorchis sinensis infection is an important risk factor for cholangiocarcinoma (CCA). It has been reported that extracellular vesicles (EVs) are involved in the parasite-host interaction, and EVs of C. sinensis (CsEVs) can contribute to biliary injuries and inflammation. However, uncertainty surrounds the function of CsEVs in the progression of CCA. In this study, differential ultracentrifugation was used to...

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Identifiers

PMID: 39466826
DOI: 10.1371/journal.pntd.0012545
PMCID: PMC11516169

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