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Article

Suppression of mRNAs encoding CD63 family tetraspanins from the carcinogenic liver fluke Opisthorchis viverrini results in distinct tegument phenotypes.

Scientific reports - 30 Oct 2017

Chaiyadet Sujittra, Krueajampa Watchara, Hipkaeo Wiphawi, Plosan Yada, Piratae Supawadee, Sotillo Javier, Smout Michael, Sripa Banchob, Brindley Paul J, Loukas Alex, Laha Thewarach

Abstract excerpt

The liver fluke Opisthorchis viverrini infects 10 million people in Southeast Asia and causes cholangiocarcinoma (CCA). Fluke secreted and tegumental proteins contribute to the generation of a tumorigenic environment and are targets for drug and vaccine-based control measures. Herein, we identified two tetraspanins belonging to the CD63 family (Ov-TSP-2 and Ov-TSP-3) that are abundantly expressed in the tegument...

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Identifiers

PMID: 29084967
DOI: 10.1038/s41598-017-13527-5
PMCID: PMC5662742

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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