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Article

Phosphodiesterase sequence variants may predispose to prostate cancer.

Endocrine-related cancer - 1 Aug 2015

de Alexandre Rodrigo B, Horvath Anelia D, Szarek Eva, Manning Allison D, Leal Leticia F, Kardauke Fabio, Epstein Jonathan A, Carraro Dirce M, Soares Fernando A, Apanasovich Tatiyana V, Stratakis Constantine A, Faucz Fabio R

Abstract excerpt

We hypothesized that mutations that inactivate phosphodiesterase (PDE) activity and lead to increased cAMP and cyclic guanosine monophosphate levels may be associated with prostate cancer (PCa). We sequenced the entire PDE coding sequences in the DNA of 16 biopsy samples from PCa patients. Novel mutations were confirmed in the somatic or germline state by Sanger sequencing. Data were then compared to the 1000...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25979379
DOI: 10.1530/ERC-15-0134
PMCID: PMC4499475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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