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Article

Identification and phenotype characterization of two CYP3A haplotypes causing different enzymatic capacity in fetal livers.

Clinical pharmacology and therapeutics - 1 Apr 2005

Rodríguez-Antona Cristina, Jande Mary, Rane Anders, Ingelman-Sundberg Magnus

Abstract excerpt

BACKGROUND: The fetal liver cytochrome P450 (CYP) 3A enzymes metabolize potentially toxic and teratogenic substrates and drugs in addition to endogenous hormones and differentiation factors. CYP3A7 is the most abundant CYP in the human liver during fetal stages and the first months of postnatal age and shows a large interindividual variability of unknown molecular basis. METHODS: A new variant gene...

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Identifiers

PMID: 15903124
DOI: 10.1016/j.clpt.2004.11.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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