Article
Directed evolution of a far-red fluorescent rhodopsin.
Proceedings of the National Academy of Sciences of the United States of America - 9 Sept 2014
McIsaac R Scott, Engqvist Martin K M, Wannier Timothy, Rosenthal Adam Z, Herwig Lukas, Flytzanis Nicholas C, Imasheva Eleonora S, Lanyi Janos K, Balashov Sergei P, Gradinaru Viviana, Arnold Frances H
Abstract excerpt
Microbial rhodopsins are a diverse group of photoactive transmembrane proteins found in all three domains of life. A member of this protein family, Archaerhodopsin-3 (Arch) of halobacterium Halorubrum sodomense, was recently shown to function as a fluorescent indicator of membrane potential when expressed in mammalian neurons. Arch fluorescence, however, is very dim and is not optimal for applications in...
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