Article
A blue-shifted light-driven proton pump for neural silencing.
The Journal of biological chemistry - 12 Jul 2013
Sudo Yuki, Okazaki Ayako, Ono Hikaru, Yagasaki Jin, Sugo Seiya, Kamiya Motoshi, Reissig Louisa, Inoue Keiichi, Ihara Kunio, Kandori Hideki, Takagi Shin, Hayashi Shigehiko
Abstract excerpt
Ion-transporting rhodopsins are widely utilized as optogenetic tools both for light-induced neural activation and silencing. The most studied representative is Bacteriorhodopsin (BR), which absorbs green/red light (∼570 nm) and functions as a proton pump. Upon photoexcitation, BR induces a hyperp...
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