Article
Effect of the PPARG2 Pro12Ala Polymorphism on Associations of Physical Activity and Sedentary Time with Markers of Insulin Sensitivity in Those with an Elevated Risk of Type 2 Diabetes.
PloS one - 1 Jan 2015
Yates Thomas, Davies Melanie J, Henson Joseph, Edwardson Charlotte, Webb David, Bodicoat Danielle H, Webb M'Balu, Howard Philip, Cooper Jackie A, Humphries Steve E, Khunti Kamlesh, Talmud Philippa
Abstract excerpt
BACKGROUND: Peroxisome proliferator-activated receptor gamma (PPARγ) is an important regulator of metabolic health and a common polymorphism in the PPAR-γ2 gene (PPARG2) may modify associations between lifestyle behaviour and health. OBJECTIVE: To investigate whether the PPARG2 Pro12Ala genotype modifies the associations of sedentary behaviour and moderate-to-vigorous intensity physical activity (MVPA) with...
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