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Article

Conservation of the STING-Mediated Cytosolic DNA Sensing Pathway in Zebrafish

14 May 2015

Abstract excerpt

UNLABELLED: Zebrafish (Danio rerio) is a unique potential model animal for dissecting innate immune signaling. Here we demonstrate that herpes simplex virus 1 (HSV-1) could infect zebrafish at its different developmental stages and trigger the expression of type I interferons (IFNs) as well as interferon-stimulated genes (ISGs) in zebrafish larvae. Silencing of zSTING, but not zMAVS, markedly attenuates the DNA...

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PMID: 25972544
DOI: 10.1128/jvi.01049-15

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