NF-κB induces miR-148a to sustain TGF-β/Smad signaling activation in glioblastoma.

Abstract excerpt

BACKGROUND: Inflammatory cytokines and transforming growth factor-β (TGF-β) are mutually inhibitory. However, hyperactivation of nuclear factor-κB (NF-κB) and TGF-β signaling both emerge in glioblastoma. Here, we report microRNA-148a (miR-148a) overexpression in glioblastoma and that miR-148a directly suppressed Quaking (QKI), a negative regulator of TGF-β signaling. METHODS: We determined NF-κB and TGF-β/Smad...

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