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Article

Serum and cellular ribavirin pharmacokinetic and concentration-effect analysis in HCV patients receiving sofosbuvir plus ribavirin.

The Journal of antimicrobial chemotherapy - 1 Aug 2015

Rower Joseph E, Meissner Eric G, Jimmerson Leah C, Osinusi Anu, Sims Zayani, Petersen Tess, Bushman Lane R, Wolfe Pamela, McHutchison John G, Kottilil Shyamasundaran, Kiser Jennifer J

Abstract excerpt

OBJECTIVES: Ribavirin concentrations may impact hepatitis C virus (HCV) treatment outcome. We modelled ribavirin serum and intracellular ribavirin monophosphate (RBV-MP) and ribavirin triphosphate (RBV-TP) pharmacokinetics in red blood cells (RBC) using samples collected during the NIAID SPARE trial to explore associations with treatment outcome and the development of anaemia. PATIENTS AND METHODS: Individuals...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25971261
DOI: 10.1093/jac/dkv122
PMCID: PMC4542804

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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