Article
ITPA deficiency and ribavirin level are still predictive of anaemia in HCV-HIV-coinfected patients receiving ribavirin combined with a first-generation DAA (ANRS HC27 study).
Antiviral therapy - 1 Jan 2017
Kheloufi Farid, Poizot-Martin Isabelle, Garraffo Rodolphe, Tavenard Aude, Quaranta Sylvie, Renault Alain, Lavrut Thibault, Bourlière Marc, Halfon Philippe, Piroth Lionel, Bellissant Eric, Lacarelle Bruno, Molina Jean-Michel, Solas Caroline
Abstract excerpt
BACKGROUND: We aimed to determine the impact of inosine triphosphatase (ITPA) deficiency on ribavirin (RBV)-induced anaemia in HIV-HCV-coinfected patients receiving a triple therapy including the haematotoxic direct-acting antiviral agent boceprevir (BOC). METHODS: Patients of the ANRS HC27 BocepreVIH study were genotyped for two ITPA single nucleotide polymorphisms involved in ITPA deficiency. RBV trough...
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