Article
[New disease markers within the chronic myeloproliferative neoplasms].
Ugeskrift for laeger - 4 May 2015
Holmström Morten Orebo, Ocias Lukas Frans, Kallenbach Klaus, Kjær Lasse, Kristensen Thomas Kielsgaard, Pallisgaard Niels, Petersen Bodil Laub, Skov Vibe, de Stricker Karin, Larsen Thomas Stauffer, Hasselbalch Hans Carl
Abstract excerpt
The chaperone and calcium storing protein calreticulin is coded by CALR, and newly identified mutations in CALR are found in respectively 49-70% and 56-88% of JAK2- and MPL-negative patients with essential thrombocytaemia (ET) and primary myelofibrosis (PMF). A total of 41 mutations have been identified, all located to exon 9 which codes the protein's C-terminal. CALR mutations are present only in myeloid...
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