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Article

Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas.

Acta neuropathologica - 1 Oct 2009

Hartmann Christian, Meyer Jochen, Balss Jörg, Capper David, Mueller Wolf, Christians Arne, Felsberg Jörg, Wolter Marietta, Mawrin Christian, Wick Wolfgang, Weller Michael, Herold-Mende Christel, Unterberg Andreas, Jeuken Judith W M, Wesseling Peter, Reifenberger Guido, von Deimling Andreas

Abstract excerpt

Somatic mutations in the IDH1 gene encoding cytosolic NADP+-dependent isocitrate dehydrogenase have been shown in the majority of astrocytomas, oligodendrogliomas and oligoastrocytomas of WHO grades II and III. IDH2 encoding mitochondrial NADP+-dependent isocitrate dehydrogenase is also mutated in these tumors, albeit at much lower frequencies. Preliminary data suggest an importance of IDH1 mutation for prognosis...

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Identifiers

PMID: 19554337
DOI: 10.1007/s00401-009-0561-9

Genes

IDH1
IDH2

Variants

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Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas.PMID 19554337Read ↗

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