Article
Genetic variation of genes involved in dihydrotestosterone metabolism and the risk of prostate cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2010
Setlur Sunita R, Chen Chen X, Hossain Ruhella R, Ha Jung Sook, Van Doren Vanessa E, Stenzel Birgit, Steiner Eberhard, Oldridge Derek, Kitabayashi Naoki, Banerjee Samprit, Chen Jin Yun, Schäfer Georg, Horninger Wolfgang, Lee Charles, Rubin Mark A, Klocker Helmut, Demichelis Francesca
Abstract excerpt
PURPOSE: Dihydrotestosterone (DHT) is an important factor in prostate cancer (PCA) genesis and disease progression. Given PCA's strong genetic component, we evaluated the possibility that variation in genes involved in DHT metabolism influence PCA risk. EXPERIMENTAL DESIGN: We investigated copy n...
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