Clinical advances and challenges in targeting FGF/FGFR signaling in lung cancer

Abstract excerpt

Fibroblast growth factors (FGFs) and their receptors regulate numerous cellular processes, such as metabolism and signal transduction, but can also drive tumorigenesis. Specifically, in lung cancer, the overexpression of FGFs, as well as the amplification, mutation and fusion of FGFR genes, are closely linked to the initiation, progression and resistance of the disease, suggesting that targeting FGF/FGFR is an...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Epigenetics and DNA Methylation
• Share to Fibroblast Growth Factor Research
• Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis