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Article

Transcriptional changes associated with resistance to inhibitors of epidermal growth factor receptor revealed using metaanalysis.

BMC cancer - 7 May 2015

Younis Sidra, Javed Qamar, Blumenberg Miroslav

Abstract excerpt

BACKGROUND: EGFR is important in maintaining metabolic homeostasis in healthy cells, but in tumors it activates downstream signaling pathways, causing proliferation, angiogenesis, invasion and metastasis. Consequently, EGFR is targeted in cancers using reversible, irreversible or antibody inhibitors. Unfortunately, tumors develop inhibitor resistance by mutations or overexpressing EGFR, or its ligand, or...

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Share to Antineoplastic Agents
Share to Cell Line, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

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Source

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Identifiers

PMID: 25948104
DOI: 10.1186/s12885-015-1337-3
PMCID: PMC4430867

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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