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Article

Association of SMAD4 loss with drug resistance in clinical cancer patients: A systematic meta-analysis

28 May 2021

Abstract excerpt

BACKGROUND: Drug resistance frequently led to the failure of chemotherapy for malignant cancers, hence causing cancer relapse. Thus, understanding mechanism of drug resistance in cancer is vital to improve the treatment efficacy. Here, we aim to evaluate the association between SMAD4 expression and the drug resistance in cancers by performing a meta-analysis. METHOD: Relevant studies detecting SMAD4 expression in...

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PMID: 34048444
DOI: 10.1371/journal.pone.0250634

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