Article
Clinical utility of plasma Epstein-Barr virus DNA and ERCC1 single nucleotide polymorphism in nasopharyngeal carcinoma.
Cancer - 15 Aug 2015
Hui Edwin P, Ma Brigette B Y, Chan K C Allen, Chan Charles M L, Wong Cesar S C, To Ka Fai, Chan Anthony W H, Tung Stewart Y, Ng Wai-Tong, Cheng Ashley C, Lee Victor H F, Chan Stephen L, Loong Herbert H F, Kam Michael K M, Leung Sing-Fai, Ho Rosalie, Mo Frankie, Ngan Roger K C, Chan Anthony T C
Abstract excerpt
BACKGROUND: Single nucleotide polymorphism (SNP) of the excision repair cross-complementing group 1 (ERCC1) gene has been linked with sensitivity to platinum and radiation. The authors hypothesized that the ERCC1 genotype for the SNPs cytosine-to-thymine substitution at codon 118 (C118T) and cytosine-to-adenine substitution at codon 8092 (C8092A) is prognostic in patients with nasopharyngeal carcinoma (NPC) who...
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