Article
Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jul 2015
Garzón-Ospina Diego, Forero-Rodríguez Johanna, Patarroyo Manuel A
Abstract excerpt
Detecting natural selection signals in Plasmodium parasites antigens might be used for identifying potential new vaccine candidates. Fifty-nine Plasmodium vivax-Sal-I genes encoding proteins having a potential role in invasion were used as query for identifying them in recent P. vivax strain genome sequences and two closely-related Plasmodium species. Several measures of DNA sequence variation were then...
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