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Article

p16 Hypermethylation and KRAS Mutation Are Independent Predictors of Cetuximab Plus FOLFIRI Chemotherapy in Patients with Metastatic Colorectal Cancer.

Cancer research and treatment - 1 Jan 2016

Kim Se Hyun, Park Kyu Hyun, Shin Sang Joon, Lee Kang Young, Kim Tae Il, Kim Nam Kyu, Rha Sun Young, Roh Jae Kyung, Ahn Joong Bae

Abstract excerpt

PURPOSE: Hypermethylation of the CpG island of p16(INK4a) occurs in a significant proportion of colorectal cancer (CRC). We aimed to investigate its predictive role in CRC patients treated with 5-fluorouracil, leucovorin, irinotecan (FOLFIRI), and cetuximab. MATERIALS AND METHODS: Pyrosequencing was used to identify KRAS mutation and hypermethylation of 6 CpG island loci (p16, p14, MINT1, MINT2, MINT31, and...

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Source

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Identifiers

PMID: 25943321
DOI: 10.4143/crt.2014.314
PMCID: PMC4720076

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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