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Mode of Action and Bactericidal Properties of Surotomycin against Growing and Nongrowing Clostridium difficile

10 Jun 2015

Abstract excerpt

Surotomycin (CB-183,315), a cyclic lipopeptide, is in phase 3 clinical development for the treatment of Clostridium difficile infection. We report here the further characterization of the in vitro mode of action of surotomycin, including its activity against growing and nongrowing C. difficile. This was assessed through time-kill kinetics, allowing a determination of the effects on the membrane potential and...

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PMID: 26055381
DOI: 10.1128/aac.01087-15

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